Basically you have to install either Crossover (https://www.codeweavers.com/crossover) or Wine (https://www.winehq.org/)
- You then create a "bottle" (a simulated Windows environment) - select Win10.
- Then install MES
- Then install .NET Framework 3.5 (there is an automated process to do this in Crossover)
- Then configure the USB port to appear as a COM port (see instructions here: https://www.codeweavers.com/support/wiki/mac/mactutorial/usbtoserial2)
- Then Load MES!